Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

摘要

BackgroundDNA methylation is an epigenetic modification that changes with age in human tissues, although the mechanisms and specificity of this process are still poorly understood. We compared CpG methylation changes with age across 283 human blood, brain, kidney, and skeletal muscle samples using methylation arrays to identify tissue-specific age effects.