The Direction of Linkage Disequilibrium: A New Measure Based on the Ancestral-Derived Status of Segregating Alleles

摘要

A new measure of directional linkage disequilibrium is developed for detecting epistatic selection on interacting genes. Simulations show that by orienting the direction of linkage disequilibrium on the basis of the ancestral-derived status of alleles, the new measure indeed improves the power to detect a positive fitness interaction between two new mutations.