Propofol-Associated Priapism in a Prepubescent PediatricPatient

摘要

Introduction. Propofol is a commonly used sedative medication for procedural sedation with a limited side effect profile. Although well tolerated with minimal adverse reactions, uncommon side effects have been reported. Methods. Case report of priapism in a 9-year-old male following the use of propofol for sedation in the pediatric intensive care unit (PICU) setting. The patient was admitted to the PICU for postoperative management following laryngotracheal reconstruction. On postoperative day 2, our patient was initiated on continuous infusion of propofol and he developed priapism. Propofol was then immediately discontinued, and the priapism quickly resolved without any medical or surgical interventions. Results. Priapism is a low-flow state and is considered a urological emergency requiring prompt recognition, withdrawal of suspected offending agents, and possible need for urologic consultation to alleviate complications. Although rare, priapism with propofol has been reported but never in a prepubescent male. The mechanism of propofol-associated priapism is not well understood, but it is thought that it may result from an autonomic system imbalance, leading to an increase in parasympathetic activity. In addition,propofol has been shown to affect nitric oxide–mediated smooth musclerelaxation. In our patient, we suspected propofol to be contributing factor tohis priapism based on the temporal relationship between the initiation of themedication and symptoms and resolution of symptoms after propofoldiscontinuation. Discussion. Given the expansive use ofpropofol in pediatrics for sedation and anesthesia, pediatric clinicians shouldbe cognizant of this rare adverse effect in pediatric patients with potentiallydisastrous complications.