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Association of IL28B Genotypes and Baseline Serum Interferon-γ-Inducible-Protein-10 Levels with Treatment Response in Hepatitis C Virus Patients in China

机译：中国丙型肝炎病毒患者IL28B基因型和基线血清干扰素-γ-诱导蛋白10水平与治疗反应的关系

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摘要

Background/AimsSeveral studies have demonstrated that serum interferon-γ-inducible-protein-10 (IP-10) levels at baseline and single nucleotide polymorphisms (SNPs) near the IL28B gene were associated with viral response and treatment outcomes. Our purpose was to assess the combination of pretreatment IP-10 levels with IL28B SNPs as predictors of treatment response to pegylated interferon α-2a plus ribavirin in patients infected with genotype 1 hepatitis C virus in China.

机译：背景/目的多项研究表明，基线时的血清干扰素-γ-诱导蛋白10（IP-10）水平和IL28B基因附近的单核苷酸多态性（SNP）与病毒反应和治疗效果相关。我们的目的是评估在中国感染基因型1型肝炎的患者中，治疗前IP-10水平与IL28B SNPs的组合作为预测对聚乙二醇化干扰素α-2a加利巴韦林治疗反应的指标。

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期刊名称 Gut and Liver
作者
Renwen Zhang; Cuiping Shao; Na Huo; Minran Li; Xiaoyuan Xu;
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作者单位

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年(卷),期 2016(10),3
年度 2016
页码 446–455
总页数 10
原文格式 PDF
正文语种
中图分类肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
关键词
Interferon-γ-inducible-protein-10 IL28B Viral response Pegylated interferon α-2a plus ribavirin;

机译：干扰素-γ-诱导蛋白-10;IL28B;病毒应答;聚乙二醇化干扰素α-2a加利巴韦林;

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专利

1. Association of IL28B Genotypes and Baseline Serum Interferon-γ-Inducible-Protein-10 Levels with Treatment Response in Hepatitis C Virus Patients in China [J] . Renwen Zhang Cuiping Shao Na Huo Minran Li, Xiaoyuan Xu Gut and Liver . 2016,第3期

机译：中国丙型肝炎病毒患者IL28B基因型和基线血清干扰素-γ-诱导蛋白10水平与治疗反应的关系
2. Lead-in treatment with interferon-??/ribavirin may modify the early hepatitis C virus dynamics in pegylated interferon alpha-2b/ribavirin combination for chronic hepatitis C patients with the IL28B minor genotype [J] . ItokawaN., AtsukawaM., TsubotaA., Journal of gastroenterology and hepatology . 2013,第3期

机译：干扰素-β/利巴韦林的导入治疗可能会改变聚乙二醇化干扰素α-2b/利巴韦林联合治疗IL28B小基因型慢性丙型肝炎患者的早期丙型肝炎病毒动力学
3. Association of interferon-gamma-induced protein-10 serum levels with virological responses to PEG-interferon-based therapy in hepatitis C virus genotype 1 or 2 chronically infected Chinese patients [J] . Wang Jianghua, Jiang Dong, Rao Huiying, Scandinavian journal of gastroenterology. . 2014,第11期

机译：丙型肝炎病毒基因型1或2慢性感染中国患者中干扰素-γ诱导的蛋白10血清水平与基于PEG-干扰素的治疗的病毒学应答的相关性
4. Hepatitis C Virus Genotyping and Serum Anti-F Antibody Detection of HCV Patients in the South of Jiangsu Province of China [C] . Xiao-Zhao Deng, Yun Zhang, Zhen-Yu Diao, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：苏南地区丙型肝炎患者丙型肝炎病毒基因分型和血清抗F抗体检测
5. Discrepancy between hepatitis C virus genotypes and NS4-based serotypes: Association with their subgenomic sequences [D] . NAN NWE, Win 2019

机译：丙型肝炎病毒基因型和基于NS4的血清型之间的差异：与它们的亚基因组序列相关
6. IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population [O] . Xiaodong Shi, Yu Pan, Moli Wang, 2009

机译：IL28B遗传变异与中国人群中丙型肝炎病毒的自发清除，治疗反应，血清IL-28B水平相关
7. IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population [O] . Shi, Xiaodong, Pan, Yu, Wang, Moli, 2012

机译：IL28B遗传变异与中国人群中丙型肝炎病毒的自发清除，治疗反应，血清IL-28B水平相关

Association of IL28B Genotypes and Baseline Serum Interferon-γ-Inducible-Protein-10 Levels with Treatment Response in Hepatitis C Virus Patients in China

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