Artesunate: Investigational Drug for the Treatment of Severe Falciparum Malaria in Hawai‘i

摘要

IntroductionThere are hundreds of millions of cases of malaria each year worldwide resulting in a million deaths. These deaths are mostly due to >Plasmodium falciparum. The only Federal Drug Administration approved treatment for severe malaria is intravenous quinidine gluconate. Intravenous quinidine is increasingly unavailable in the United States. In 2007, the Center for Disease Control and Prevention implemented an investigational new drug protocol to allow the use of intravenous artesunate for cases of severe malaria in the United States. The authors present such a case treated under this protocol at Tripler Army Medical Center, Hawai‘i.