Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation

摘要

An unusual case of mucoepidermoid carcinoma (MEC) of intraoral minor salivary gland origin with spindled morphology was presented. A fascicular stream of bland spindle cells from typical MEC areas amounted to more than 70% of the tumor. Spindle population had features consistent with immunohistochemical and ultrastructural profiles of intermediate cells and lacked overexpression of p53 and cyclin D1. There was no difference in the Ki-67 index between two distinct components. Awareness of extensive spindle cell change replacing a significant portion of low-grade MEC is crucial to avoid an erroneous interpretation of dedifferentiated sarcomatoid transformation.