Critical role of the CD40–CD40‐ligand pathway in regulating mucosal inflammation‐driven angiogenesis in inflammatory bowel disease

摘要

Background and aimsAngiogenesis is a novel component in inflammatory bowel disease (IBD) pathogenesis. We have previously shown that immune–nonimmune interactions through the CD40–CD40‐ligand (CD40L) pathway might sustain gut inflammation, although their effect on regulating inflammation‐driven angiogenesis is unknown. The present study evaluated the role of the CD40–CD40L interaction in the promotion of immune‐mediated angiogenesis in IBD.