BACKGROUND/AIMS: Calcium and vitamin D malabsorption in coeliac disease predispose to skeletal demineralisation. This study aimed to determine bone mineral density in patients studied in the first year after diagnosis of coeliac disease, and to detect changes in bone mineral density over the subsequent year. METHODS: Lumbar spine and femoral neck bone mineral density was measured in 21 adults with coeliac disease, diagnosed and started on a gluten free diet during the preceding year, with dual energy x ray absorptiometry and repeated after 12 months. RESULTS: Bone mineral density was significantly lower in patients than in paired controls (matched for age and sex), at lumbar spine (0.819 g/cm2 compared with 1.021 g/cm2, p < 0.001 Wilcoxon signed rank test) and femoral neck (0.663 g/cm2 compared with 0.794 g/cm2, p < 0.001). Repeat measurement after 12 months demonstrated that patients had a significant gain in bone mineral density at lumbar spine (16.6%/year), and femoral neck (15.5%/year, p < 0.002, Wilcoxon signed rank test at both sites), whereas no significant change in bone mineral density was detected in controls. CONCLUSIONS: Treatment of coeliac disease with a gluten free diet is associated with a significant increase in bone mineral density, although patients still had lower bone mineral density than controls.
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机译：背景/目的：乳糜泻中的钙和维生素D吸收不良易导致骨骼脱矿质。这项研究的目的是确定腹腔疾病诊断后第一年所研究患者的骨矿物质密度，并在随后的一年中检测骨矿物质密度的变化。方法：对21名成人腹腔疾病成年人的腰椎和股骨颈骨矿物质密度进行了测量，在上一年中被诊断为无麸质饮食并开始使用双能X线骨密度仪，并在12个月后重复进行。结果：在腰椎（0.819 g / cm2比1.021 g / cm2，p <0.001 Wilcoxon符号秩检验）和股骨颈（0.663）下，患者的骨矿物质密度显着低于配对对照（年龄和性别匹配） g / cm2，而0.794 g / cm2，p <0.001）。 12个月后重复测量表明，患者的腰椎骨密度（16.6％/年）和股骨颈（15.5％/年，p <0.002，Wilcoxon符号秩和检验在两个部位）均有显着增加，而无在对照中检测到骨矿物质密度的显着变化。结论：尽管患者的骨矿物质密度仍低于对照组，但无麸质饮食治疗乳糜泻与骨矿物质密度显着增加有关。
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