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Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection

机译:关于幽门螺杆菌感染过程中CD8 + T细胞的作用和细胞毒性反应的新见解

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摘要

Helicobacter pylori chronically persists in 50% of the human population and causes serious gastric and duodenal pathologies in 15% of infected people. Research on the immune response to the infection has mainly focused on the induction of CD4+ T cell responses. Human studies emphasize the potential clinical relevance of CD8+ cytotoxic T lymphocytes, however this cell type has barely been reported in studies employing mouse or gerbil models. Traditionally characterized as an extracellular bacterium, H. pylori has been identified inside epithelial and immune cells. Similarly to other intracellular bacteria, H. pylori infection of macrophages can alter autophagy and phagosome processing. A novel animal model of H. pylori infection demonstrates for the first time the induction of cytotoxic CD8+ T cell responses in pigs and localization of intracellular H. pylori within lymphoid aggregates. Here, we discuss novel mechanisms of host-H. pylori interactions that could lead to the induction of cytotoxic responses.
机译:幽门螺杆菌长期存在于50%的人口中,并在15%的感染者中引起严重的胃和十二指肠病变。对感染的免疫反应的研究主要集中在诱导CD4 + T细胞反应上。人体研究强调了CD8 +细胞毒性T淋巴细胞的潜在临床意义,但是在使用小鼠或沙鼠模型的研究中几乎没有报道过这种细胞类型。幽门螺杆菌通常被表征为细胞外细菌,已在上皮细胞和免疫细胞内被发现。与其他细胞内细菌相似,巨噬细胞的幽门螺杆菌感染可以改变自噬和吞噬体加工。幽门螺杆菌感染的新型动物模型首次证明了猪细胞毒性CD8 + T细胞反应的诱导和淋巴聚集物中细胞内幽门螺杆菌的定位。在这里,我们讨论宿主H的新颖机制。幽门螺杆菌相互作用,可能导致细胞毒性反应的诱导。

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