Inhibition of hepatitis B virus gene expression replication by crude destruxins from Metarhizium anisopliae var. dcjhyium

摘要

Background & objectives:Destruxin A, destruxin B and destruxin E isolated from entomopathogenic fungus Metarhizium anisopliae showed a strong suppressive effect on the replication of hepatitis B virus (HBV) in human hepatoma cells. In this study, the anti-HBV effects of the crude destruxins extracted from M. anisopliae var. dcjhyium were detected both in vitro and in vivo.