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Possible role of CYP2C9 CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy

机译：CYP2C9和CYP2C19单核苷酸多态性在药物难治性癫痫中的可能作用

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Background & objectivesMultiple drug resistance in epilepsy is a common problem and one third of epilepsy patients remain non responsive to antiepileptic drug (AED) therapy. In this study we aimed to investigate the relationship between the genetic polymorphism of cytochrome P450 genes, namely CYP2C9 and CYP2C19 with multiple drug resistance in epilepsy patients.

机译：背景与目的癫痫的多种耐药性是一个普遍的问题，三分之一的癫痫患者对抗癫痫药（AED）的治疗仍然无反应。在这项研究中，我们旨在研究癫痫患者细胞色素P450基因CYP2C9和CYP2C19的遗传多态性与多重耐药的关系。

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期刊名称 The Indian Journal of Medical Research
作者
Ram Lakhan; Ritu Kumari; Kavita Singh; Jayanti Kalita; Usha Kant Misra; Balraj Mittal;
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作者单位

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年(卷),期 2011(134),3
年度 2011
页码 295–301
总页数 1
原文格式 PDF
正文语种
中图分类基础医学 ; 免疫学 ; 医学史 ;
关键词
Cytochrome drug refractory epilepsy P450 pharmacogenetics single nucleotide polymorphism;

机译：细胞色素;药物难治性;癫痫;P450;药物遗传学;单核苷酸多态性;

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专利

1. Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy. [J] . Lakhan R, Kumari R, Singh K, The Indian journal of medical research. . 2011 ,第3期

机译：CYP2C9和CYP2C19单核苷酸多态性在药物难治性癫痫中的可能作用。
2. Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy [J] . Ram Lakhan, Ritu Kumari, Kavita Singh, The Indian journal of medical research . 2011 ,第3期

机译：CYP2C9和CYP2C19单核苷酸多态性在药物难治性癫痫中的可能作用
3. Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy [J] . Manna Jose, Moinak Banerjee, Anila Mathew, Annals of Indian Academy of Neurology . 2014 ,第3期

机译：ABCB1，Cyp2C9，Cyp2C19和亚甲基四氢叶酸还原酶基因多态性对癫痫女性抗癫痫药致畸性的药理学评价
4. Exploring genetic variability in drug therapy by selecting a minimum subset of the most informative single nucleotide polymorphisms through approximation of a markov blanket in a kernel-induced space [C] . Lou Qiang, Parkman Henry P., Jacobs Michael R., Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), 2012 IEEE Symposium on . 2012

机译：通过在籽粒诱导的空间中通过近似马可夫毯选择最丰富的单核苷酸多态性的最小子集来探索药物治疗中的遗传变异性
5. The role of the beta-1,2-adrenergic and GRK5 receptor single-nucleotide-polymorphisms on the treatment of heart failure with beta-blockers. [D] . Rogers, Hobart Lee, Jr. 2010

机译：β-1,2-肾上腺素和GRK5受体单核苷酸多态性在使用β-受体阻滞剂治疗心力衰竭中的作用。
6. CYP2C9 promoter region single-nucleotide polymorphisms linked to the R150H polymorphism are functional suggesting their role in CYP2C9*8-mediated effects [O] . Larisa H. Cavallari, David Vaynshteyn, Kimberly M. Freeman, -1

机译：与R150H多态性相关的CYP2C9启动子区域单核苷酸多态性起作用表明它们在CYP2C9 * 8介导的作用中的作用
7. Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population [O] . Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, 2021

机译：泰国人群中临床重要药物代谢酶CYP2C9，CYP2C19和CYP3A4的单核苷酸多态性的等位基因频率

Possible role of CYP2C9 CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy

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