The activity of a mammalian proline-rich peptide against Gram-negative bacteria including drug-resistant strains relies on a nonmembranolytic mode of action

摘要

BackgroundA peptide of 2,733 Da named SP-E, previously isolated from pig saliva and already described for its antifungal activity and absence of toxicity against mammalian cells, is characterized by a high content of proline residues (70% of entire sequence), that confer structural features probably related to peptide activity.