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Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement.

机译:脑膜炎奈瑟菌菌血症与补体第六成分不足有关。

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摘要

The serum of a 26-year-old black man with a recent episode of meningococcemia complicated by meningitis and arthritis was found to lack hemolytic complement activity. The sixth component of complement was not detected by functional or immunochemical assays whereas other components were normal by hemolytic assay. His fresh acute-phase serum lacked complement-mediated bactericidal activity against the homologous strain of Neisseria meningitidis, but the addition of fresh normal serum or purified C6 restored bactericidal activity as well as hemolytic activity. The absence of C6 activity could not be accounted for on the basis of an inhibitor. Opsonization and chemotaxis functioned normally. Histocompatibility typing of family members did not demonstrate evidence for genetic linkage of C6 deficiency with the major histocompatibility loci. This report represents the first published case of C6 deficiency associated with bacteremic Neisseria infections in which antimeningococcal bactericidal antibodies have been definitively demonstrated against the homologous strain in the acute phase of the illness.
机译:发现一名26岁的黑人,患有近期的脑膜炎球菌血症并发脑膜炎和关节炎,其血清缺乏溶血补体活性。通过功能或免疫化学分析未检测到补体的第六种成分,而通过溶血分析则其他成分正常。他的新鲜急性期血清缺乏针对脑膜炎奈瑟氏球菌同源菌株的补体介导的杀菌活性,但是添加新鲜的正常血清或纯化的C6可以恢复杀菌活性和溶血活性。不能基于抑制剂来解释C6活性的缺乏。调理作用和趋化作用正常。家庭成员的组织相容性分型没有显示C6缺乏症与主要组织相容性基因座的遗传联系的证据。该报告代表了首次公开发表的与细菌性奈瑟氏菌感染有关的C6缺乏症病例,其中已经明确证明了在该病急性期针对该同源菌株的抗脑膜炎球菌杀菌抗体。

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