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Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

机译:放疗恶性肿瘤患者血清铜水平的变化

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摘要

Present study repots changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40–70 Gy in 4–7 weeks. SCLs were again estimated in patients following irradiation. The mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.
机译:本研究报告了接受放疗的各种肿瘤疾病中血清铜水平(SCL)的变化。我们估计了140名个体中的SCL,其中包括90名先前未经治疗的各种恶性肿瘤患者和50名健康对照。患者在4-7周内接受了40-70 Gy的辐射。辐照后再次评估患者的SCL。与健康对照组相比,癌症患者的平均SCL显着更高(P <0.001)。辐照后明显下降(P <0.001)。然而,与健康对照相比,它仍然显着更高(P <0.01)。在完全临床反应者中,SCL下降最高,而对放射治疗无反应者中,SCL下降幅度最小。 SCL的串行估计可能在监测正在接受放射治疗的肿瘤的治疗中很有用。

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