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Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats

机译：过度表达Nurr1的神经干细胞和小胶质细胞的移植治疗帕金森病大鼠

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摘要

Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.

机译：神经干细胞（NSC）移植被认为是治疗帕金森氏病的有前途的治疗方法。但是，大多数NSC分化为神经胶质细胞而不是神经元，并且由于炎性环境，它们中只有少数能在移植后存活。

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期刊名称 CNS Drug Reviews
作者
Yuan Qian; Xiao‐Xiang Chen; Wei Wang; Jun‐Jun Li; Xian‐Peng Wang; Zhi‐Wei Tang; Jiao‐Tian Xu; Hai Lin; Zhi‐Yong Yang; Li‐Yan Li; Xiao‐Bin Song; Jia‐Zhi Guo; Li‐Gong Bian; Lei Zhou; Di Lu; Xing‐Li Deng;
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作者单位

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年(卷),期 2020(26),1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
inflammatory; microglia; neural stem cells; nuclear receptor‐related factor 1; Parkinsons disease;

机译：炎症;小胶质细胞;神经干细胞;核受体相关因子1;帕金森氏病;

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专利

1. Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats [J] . Yuan Qian, Xiao‐Xiang Chen, Wei Wang, CNS neuroscience & therapeutics. . 2020,第1期

机译：Nurr1过度抑制神经干细胞和微胶质治疗帕金森大鼠的移植
2. Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats [J] . TanX., ZhangL., QinJ., International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience . 2013,第1期

机译：Nurr1和Brn4共转染的神经干细胞移植治疗帕金森病大鼠
3. Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene [J] . Li QJ, Tang YM, Liu J, Synapse . 2007,第12期

机译：用含有NURR1基因的重组共和缺陷腺病毒用过表达NURR1的C17.2神经干细胞治疗帕金森氏病
4. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-Dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant [C] . Leona A. Holmberg, Katherine A. Guthrie, Brenda M. Sandmaier Chemical glycobiology . -1

机译：大剂量化学疗法和自体干细胞拯救治疗的Theratope（STn-KLH）癌症疫苗治疗的乳腺癌和卵巢癌患者的临床结果：自体移植后的Theratope（STn-KLH）癌症疫苗
5. Embryonic stem cell derived neural progenitor cells transplanted in tissue engineered fibrin scaffolds to treat subacute spinal cord injury. [D] . Johnson, Philip Joseph. 2009

机译：胚胎干细胞衍生的神经祖细胞移植到组织工程化的纤维蛋白支架中，以治疗亚急性脊髓损伤。
6. Nurr1 promotes neurogenesis of dopaminergic neuron and represses inflammatory factors in the transwell coculture system of neural stem cells and microglia [O] . Xiao‐Xiang Chen, Yuan Qian, Xiang‐Peng Wang, 2018

机译：Nurr1促进神经干细胞和小胶质细胞跨孔共培养系统中多巴胺能神经元的神经发生并抑制炎症因子
7. Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats [O] . Yuan Qian, Xiao‐Xiang Chen, Wei Wang, 2019

机译：Nurr1过度抑制神经干细胞和微胶质治疗帕金森大鼠的移植

Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats

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