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In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)

机译：吡咯肟肟转运和乙酰胆碱酯酶跨MDCK细胞和干细胞衍生的人脑微血管内皮细胞（BC1-hBMECs）的体外表征

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BackgroundCurrent therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Studies in animal models have shown a low concentration in the brain following systemic injection.

机译：背景技术当前用于有机磷酸酯中毒的疗法涉及给予肟，例如普利酮肟（2-PAM），其重新激活乙酰胆碱酯酶。动物模型研究表明，全身注射后大脑中的浓度较低。

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期刊名称 Cerebrospinal Fluid Research
作者
Erin Gallagher; Il Minn; Janice E. Chambers; Peter C. Searson;
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年(卷),期 2016(13),-1
年度 2016
页码 10
总页数 8
原文格式 PDF
正文语种
中图分类神经科学;
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专利

1. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs) [J] . Erin Gallagher, Il Minn, Janice E. Chambers, Cerebrospinal Fluid Research . 2016,第1期

机译：吡咯肟肟转运和乙酰胆碱酯酶在MDCK细胞和干细胞衍生的人脑微血管内皮细胞（BC1-hBMEC）上的体外表征
2. Prediction of Drug Permeability Using In Vitro Blood–Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells [J] . Makiko Ohshima, Shota Kamei, Hideo Fushimi, BioResearch open access. . 2019,第1期

机译：使用人类诱导的多能干细胞衍生的脑微血管内皮细胞的体外血脑屏障模型预测药物的渗透性
3. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells [J] . Stebbins Matthew J., Wilson Hannah K., Canfield Scott G., Methods: A Companion to Methods in Enzymology . 2016,第Null期

机译：人多能干细胞衍生的脑微血管内皮细胞的分化和鉴定
4. Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1) in Adenosine Diphosphate-Activated Platelet Adhesion to Human Brain Microvascular Endothelial Cells Under Flow In Vitro [C] . Norio Tanahashi, Yoshiaki ItohMIideki Satoh, Takato Abe, Keio International Symposia for Life Sciences and Medicine . 2005

机译：凝集素样氧化低密度脂蛋白受体-1（LOX-1）在体外流量下对人脑微血管内皮细胞的腺苷二磷酸活性血小板粘附的作用
5. Identification and functional characterization of neuronal nitric oxide synthase in primary human brain microvascular endothelial cells [D] . Gordon, Angellica O. 2015

机译：人原代人脑微血管内皮细胞中神经元一氧化氮合酶的鉴定和功能表征
6. Prediction of Drug Permeability Using In Vitro Blood–Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells [O] . Makiko Ohshima, Shota Kamei, Hideo Fushimi, 2019

机译：使用人类诱导的多能干细胞衍生的脑微血管内皮细胞的体外血脑屏障模型预测药物的渗透性
7. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs) [O] . 2016

机译：吡咯肟肟转运和乙酰胆碱酯酶跨MDCK细胞和干细胞衍生的人脑微血管内皮细胞（BC1-hBMECs）的体外表征

In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)

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