High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR- γ

机译：高脂饮食通过干预PPAR-γ上调脂肪酸氧化和酮体生成

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Background/Aims:Systemic hyperlipidemia and intracellular lipid accumulation induced by chronic high fat diet (HFD) leads to enhanced fatty acid oxidation (FAO) and ketogenesis. The present study was aimed to determine whether activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) by surplus free fatty acids (FA) in hyperlipidemic condition, has a positive feedback regulation over FAO and ketogenic enzymes controlling lipotoxicity and cardiac apoptosis.

机译：背景/目的：慢性高脂饮食（HFD）引起的系统性高脂血症和细胞内脂质蓄积导致脂肪酸氧化（FAO）和生酮作用增强。本研究旨在确定高脂血症患者体内过剩游离脂肪酸（FA）对过氧化物酶体增殖物激活受体-γ（PPAR-γ）的激活是否对FAO和控制脂肪毒性和心脏凋亡的生酮酶具有正反馈调节作用。

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期刊名称 Cellular Physiology and Biochemistry
作者
Kunal Sikder; Sanket Kumar Shukla; Neel Patel; Harpreet Singh; Khadija Rafiq;
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作者单位

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年(卷),期 -1(48),3
年度 -1
页码 1317–1331
总页数 25
原文格式 PDF
正文语种
中图分类细胞生物学;人体生理学;
关键词
High fat diet Type 2 diabetes mellitus Lipotoxicity PPAR-γ Ketone bodies HMGCS2 BDH1 PDK;

机译：高脂饮食;2型糖尿病;脂肪中毒;PPAR-γ;酮体;HMGCS2;BDH1;PDK;
入库时间 2022-08-21 10:50:59

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专利

1. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ [J] . Sikder K., Shukla S.K., Patel N., Cellular Physiology and Biochemistry . 2018,第3期

机译：高脂饮食通过干预PPAR-γ上调脂肪酸氧化和酮体生成
2. The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. [J] . Cullingford TE, Dolphin CT, Sato H Neuropharmacology . 2002,第5期

机译：过氧化物酶体增殖物激活受体α-选择性激活剂环丙纤酸酯上调大鼠脑中编码脂肪酸氧化和生酮酶的基因的表达。
3. Activation of the Peroxisome Proliferator-Activated Receptors (PPAR- α / γ ) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease [J] . Haifa M. AlNafea, Aida A. Korish PPAR research . 2021,第a期

机译：激活过氧化物体增殖物激活的受体（PPAR-α/γ）和骆驼牛奶处理脂肪酸代谢酶蛋白CPT1a抵消了高脂饮食诱导的非酒精性脂肪肝病
4. Effect of Fat Supplement Containing Docosahexaenoic Acid and Medium Chain Fatty Acid on Milk Production and Milk Fatty Acid Profiles of Dairy Cows fed Grass Silage Based Diet [C] . Maimaijiang Zunong, Masaaki Hanada, Yimamu Aibibula, New paradigm for diversity of forage production in the east Asian region . 2009

机译：含有二十二碳六烯酸和中链脂肪酸的脂肪补充剂对饲喂草青贮饲料的奶牛产奶量和乳脂特性的影响
5. Effect of varying the fatty acid composition of a carbohydrate-restricted diet on plasma fatty acid composition, blood lipids oxidative stress, inflammation and insulin sensitivity in men. [D] . Forsythe-Pribanic, Cassandra E. 2009

机译：改变限制碳水化合物饮食的脂肪酸组成对男性血浆脂肪酸组成，血脂氧化应激，炎症和胰岛素敏感性的影响。
6. Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet [O] . Fan Zheng, Ying Cai 2019

机译：同步运动通过上调高脂饮食的ApoE-KO小鼠中的PPAR-γ和脂肪酸β-氧化相关基因来改善胰岛素抵抗和非酒精性脂肪肝疾病
7. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ [O] . Kunal Sikder, Sanket Kumar Shukla, Neel Patel, 2018

机译：高脂饮食通过PPAR-γ的干预上调脂肪酸氧化和酮发生器

High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR- γ

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