Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands

摘要

Background and purpose:The introduction of fluorescence-based techniques, and in particular the development of fluorescent ligands, has allowed the study of G protein-coupled receptor pharmacology at the single cell and single molecule level. This study evaluated how the physicochemical nature of the linker and the fluorophore affected the pharmacological properties of fluorescent agonists and antagonists.