Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

机译：用低分子量化合物靶向LINGO-1的顺式二聚体会影响其下游信号传导

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Background and PurposeThe transmembrane protein LINGO-1 is a negative regulator in the nervous system mainly affecting axonal regeneration, neuronal survival, oligodendrocyte differentiation and myelination. However, the molecular mechanisms regulating its functions are poorly understood. In the present study, we investigated the formation and the role of LINGO-1 cis-dimers in the regulation of its biological activity.

机译：背景与目的跨膜蛋白LINGO-1是神经系统的负调节剂，主要影响轴突再生，神经元存活，少突胶质细胞分化和髓鞘形成。但是，对其功能调节的分子机理了解甚少。在本研究中，我们调查了LINGO-1顺式二聚体的形成及其在调节其生物学活性中的作用。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
L Cobret; M L De Tauzia; J Ferent; E Traiffort; I Hénaoui; F Godin; E Kellenberger; D Rognan; J Pantel; H Bénédetti; S Morisset-Lopez;
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作者单位

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年(卷),期 2015(172),3
年度 2015
页码 841–856
总页数 16
原文格式 PDF
正文语种
中图分类药学;
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机译：用低分子量化合物靶向LINGO-1的顺式二聚体会影响其下游信号传导

Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

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