Modulation of Kv7 potassium channels by a novel opener pyrazolo15-apyrimidin-7(4H)-one compound QO-58

摘要

Background and PurposeModulation of Kv7/M channel function represents a relatively new strategy to treat neuronal excitability disorders such as epilepsy and neuropathic pain. We designed and synthesized a novel series of pyrazolo[1,5-a] pyrimidin-7(4H)-one compounds, which activate Kv7 channels. Here, we characterized the effects of the lead compound, QO-58, on Kv7 channels and investigated its mechanism of action.