Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor

机译：咖啡酸苯乙基酯通过涉及血红素加氧酶-1和脑源性神经营养因子的双重机制保护黑色素多巴胺能神经元

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BACKGROUND AND PURPOSECaffeic acid phenethyl ester (CAPE) is a component of honey bee propolis that can induce expression of haem oxygenase-1 (HO-1). Because HO-1 induction has been suggested to protect dopaminergic neurons in the substantia nigra, we examined the effect of CAPE in experimental models of dopaminergic neurodegeneration.

机译：背景和用途咖啡酸苯乙酯（CAPE）是蜂胶的一种成分，可以诱导血红素加氧酶-1（HO-1）的表达。因为已建议HO-1诱导来保护黑质中的多巴胺能神经元，所以我们在多巴胺能神经变性的实验模型中研究了CAPE的作用。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Y Kurauchi; A Hisatsune; Y Isohama; S Mishima; H Katsuki;
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作者单位

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年(卷),期 2012(166),3
年度 2012
页码 1151–1168
总页数 18
原文格式 PDF
正文语种
中图分类药学;
关键词
brain-derived neurotrophic factor caffeic acid phenethyl ester dopaminergic neurons heme oxygenase neuroprotection Nrf2 Parkinson disease;

机译：脑源性神经营养因子;咖啡酸苯乙酯;多巴胺能神经元;血红素加氧酶;神经保护;Nrf2;帕金森病;

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专利

1. Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury. [J] . Canudas AM, Pezzi S, Canals JM, Brain research. Molecular brain research . 2005,第1期

机译：内源性脑源性神经营养因子可保护多巴胺能性黑质神经元免受纹状体兴奋性毒性损伤引起的跨神经元变性。
2. CAFFEIC ACID PHENETHYL ESTER PROTECTS AGAINST THE DOPAMINERGIC NEURONAL LOSS INDUCED BY 6-HYDROXYDOPAMINE IN RATS [J] . R. BARROS SILVA, N. A. G. SANTOS, N. M. MARTINS, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2013,第Null期

机译：咖啡酸苯酯对大鼠6-羟多巴胺引起的多巴胺能神经元丢失的保护作用
3. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells. [J] . Seki M, Tanaka T, Nawa H, Diabetes . 2004,第9期

机译：脑源性神经营养因子参与链脲佐菌素诱发的糖尿病大鼠的早期视网膜神经病变：脑源性神经营养因子对多巴胺能无长分泌细胞的治疗潜力。
4. Caffeic Acid Phenethyl Ester Protect Mice Hepatic Damage Against Cadmium Exposure [C] . Fuxin Chen, Pin Gong International Conference on Environment Science and Biotechnology . 2013

机译：咖啡酸苯乙烯酯保护小鼠肝脏损伤对镉暴露
5. Molecular mechanisms of PKCdelta in neurotoxin-induced apoptotic death of nigral dopaminergic neurons: Relevance to the pathogenesis of Parkinson's disease. [D] . Yang, Yongjie. 2005

机译：神经毒素诱导的多巴胺能神经元凋亡死亡中PKCdelta的分子机制：与帕金森氏病的发病机制有关。
6. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain [O] . B Knusel, KD Beck, JW Winslow, 1992

机译：脑源性神经营养因子的给药可保护成年大鼠大脑轴突切开后基底前脑胆碱能神经元而非黑质多巴胺能神经元免受变性改变
7. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain [O] . B Knusel, KD Beck, JW Winslow, 1992

机译：脑衍生的神经营养因子施用保护基础前脑胆能，但不是成年大鼠脑中的轴突后的退行性变化的末端多巴胺能神经元
8. Structure-Activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. [R] . Wang, X., Stavchansky, S., Kerwin, S. M., 2010

机译：咖啡酸苯乙酯（CapE）和氟化衍生物的细胞保护作用中的构效关系：对血红素氧合酶-1诱导和抗氧化活性的影响。

Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor

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