Characterization of the hypothermic effects of imidazoline I2 receptor agonists in rats

摘要

BACKGROUND AND PURPOSEImidazoline I2 receptors have been implicated in several CNS disorders. Although several I2 receptor agonists have been described, no simple and sensitive in vivo bioassay is available for studying I2 receptor ligands. This study examined I2 receptor agonist-induced hypothermia as a functional in vivo assay of I2 receptor agonism.