Pharmacological properties of S1RA a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

摘要

BACKGROUND AND PURPOSEThe sigma-1 (σ1) receptor is a ligand-regulated molecular chaperone that has been involved in pain, but there is limited understanding of the actions associated with its pharmacological modulation. Indeed, the selectivity and pharmacological properties of σ1 receptor ligands used as pharmacological tools are unclear and the demonstration that σ1 receptor antagonists have efficacy in reversing central sensitization-related pain sensitivity is still missing.