The mixed-lineage kinase 1–3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors

机译：混合谱系激酶1-3信号通路通过GATA-4和AP-1转录因子调节心肌细胞的应激反应

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摘要

Background and purpose:The mixed-lineage kinases (MLKs) act upstream of mitogen-activated protein kinases, but their role in cardiac biology and pathology is largely unknown.

机译：背景与目的：混合谱系激酶（MLK）在促分裂原活化蛋白激酶的上游起作用，但在心脏生物学和病理学中的作用尚不清楚。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
A Ola; R Kerkelä; H Tokola; S Pikkarainen; R Skoumal; O Vuolteenaho; H Ruskoaho;
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作者单位

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年(卷),期 2010(159),3
年度 2010
页码 717–725
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
MLK CEP-11004 GPCR agonists cardiac hypertrophy GATA-4 AP-1;

机译：MLK;CEP-11004;GPCR激动剂;心脏肥大;GATA-4;AP-1;

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专利

1. Epicatechin induces NF- kappa B, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling inHepG2 cells. [J] . Granado-Serrano A. B., Martin M. A., Haegeman G., The British Journal of Nutrition . 2010,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（NF-κB，活化蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）诱导。 ERK）在HepG2细胞中发出信号。
2. Epicatechin induces NF- kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling inHepG2 cells. [J] . Granado-Serrano A. B., Martin M. A., Haegeman G., The British Journal of Nutrition . 2010,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（ERK）诱导NF-κB，激活蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）。）在HeepG2细胞中发出信号。
3. Epicatechin induces NF-κB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [J] . Ana Belén Granado-Serrano, Guy Haegeman, Laura Bravo, The British Journal of Nutrition . 2009,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（ERK）诱导NF-κB，激活蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）。）在HepG2细胞中的信号转导
4. gration of protein kinase signaling pathwaysin cardiac myocytes: signaling to and from theextracellular signal-regulated kinases [C] . Angela Clerk, Timothy J. Kemp, Joanne G. Harrison, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2004

机译：蛋白质激酶信号传导途径心脏肌细胞的腺体：向外信号调节激酶的信号传导
5. PI 3-kinase signaling regulates transcription through a network of NFκB, MYC superfamily and forkhead transcription factors [D] . Terragni, Jolyon 2011

机译：PI 3-激酶信号传导通过NFκB，MYC超家族和前叉转录因子网络调节转录
6. Extracellular Signal-Regulated Kinase Signaling Regulates the Opposing Roles of JUN Family Transcription Factors at ETS/AP-1 Sites and in Cell Migration [O] . Nagarathinam Selvaraj, Justin A. Budka, Mary W. Ferris, 2015

机译：细胞外信号调节激酶信号调节JTS家族转录因子在ETS / AP-1位点和细胞迁移中的相反作用。
7. The mixed-lineage kinase 1–3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors [O] . Ola, A, Kerkelä, R, Tokola, H, 2010

机译：混合谱系激酶1-3信号通路通过GATA-4和AP-1转录因子调节心肌细胞的应激反应

The mixed-lineage kinase 1–3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors

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