Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex

摘要

Background and purpose:In vitro studies demonstrate that cannabinoid CB1 receptors subserve activity-dependent suppression of inhibition in the neocortex. To examine this mechanism in vivo, we assessed the effects of local changes in CB1 receptor activity on somatosensory cortex neuronal activation by whisker movement in rats.