Regulation of Fas receptor/Fas-asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain

摘要

Background and purpose:Natural and synthetic cannabinoids (CBs) induce deleterious or beneficial actions on neuronal survival. The Fas-associated protein with death domain (FADD) promotes apoptosis, and its phosphorylated form (p-FADD) mediates non-apoptotic actions. The regulation of Fas/FADD, mitochondrial apoptotic proteins and other pathways by CB receptors was investigated in the mouse brain.