The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

机译：磷脂酶C抑制剂U-73122通过抑制平滑肌中的Ca2 +泵来抑制Ca2 +从细胞内肌浆网Ca2 +存储中释放

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Background and purpose:The sarcoplasmic reticulum (SR) releases Ca²⁺ via inositol 1,4,5-trisphosphate receptors (IP3R) in response to IP3-generating agonists. Ca²⁺ release subsequently propagates as Ca²⁺ waves. To clarify the role of IP3 production in wave generation, the contribution of a key enzyme in the production of IP3 was examined using a phosphoinositide-specific phospholipase C (PI-PLC) inhibitor, U-73122.

机译：背景与目的：肌浆网（SR）通过肌醇1、4、5-三磷酸酯受体（IP3R）释放Ca ^{2 + ，以响应产生IP3的激动剂。随后，Ca ^{2 + 的释放随Ca ^{2 + 波的传播而传播。为了阐明IP3产生在波浪产生中的作用，使用磷酸肌醇特异性磷脂酶C（PI-PLC）抑制剂U-73122检查了关键酶在IP3产生中的作用。}}}

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
D MacMillan; JG McCarron;
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作者单位

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年(卷),期 2010(160),6
年度 2010
页码 1295–1301
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
U-73122 phospholipase C smooth muscle calcium;

机译：U-73122;磷脂酶C;平滑肌;钙;

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1. Luminal Ca2+ and the activity of sarcoplasmic reticulum Ca2+ pumps modulate histamine-induced all-or-none Ca2+ release in smooth muscle cells [J] . Rueda A., Garcia L., Guerrero-Hernandez A. Cellular Signalling . 2002,第6期

机译：发光Ca2 +和肌浆网Ca2 +泵的活性调节平滑肌细胞中组胺诱导的全或无Ca2 +释放
2. Characterization of Ca2+ release from heterogeneous Ca2+ stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle. [J] . Stout MA, Raeymaekers L, De Smedt H, Canadian Journal of Physiology and Pharmacology . 2002,第6期

机译：从动脉和胃平滑肌分离的肌质网中异质Ca2 +存储中Ca2 +释放的特征。
3. Sarcoplasmic reticulum Ca2+ refilling is determined by L-type Ca2+ and store operated Ca2+ channels in guinea pig airway smooth muscle [J] . Flores-SotoE., Reyes-GarcíaJ., SommerB., European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：肌质网Ca2 +的充盈由L型Ca2 +决定并在豚鼠气道平滑肌中存储操作的Ca2 +通道
4. Sarcoplasmic reticulum luminal Ca2+ regulates the spontaneous Ca2+ release events and consequently arrhythmia [C] . Luyao Lu, Ling Xia, Xiuwei Zhu 2010 Computers in Cardiology . 2010

机译：肌浆网腔Ca 2 + 调节自发性Ca 2 + 释放事件，从而调节心律失常
5. Mitochondrial Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Regulates Smooth Muscle Cell Migration and Neointimal Formation via Mitochondrial Ca2+ Uptake and Mobility [D] . Nguyen, Emily Kim. 2019

机译：线粒体CA2 + /钙调霉素依赖性激酶II（CAMKII）通过线粒体CA2 +摄取和移动性调节平滑肌细胞迁移和新内膜形成
6. 46-Dibromo-3-hydroxycarbazole (an analogue of caffeine-like Ca2+ releaser) a novel type of inhibitor of Ca(2+)-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum. [O] . Y Takahashi, K Furukawa, D Kozutsumi, 1995

机译：46-二溴-3-羟基咔唑（类似咖啡因的Ca2 +释放剂）一种新型的Ca（2+）诱导剂可在骨骼肌肌浆网中释放Ca2 +。
7. The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle [O] . MacMillan, D, McCarron, JG 2010

机译：磷脂酶C抑制剂U-73122通过抑制平滑肌中的Ca2 +泵来抑制Ca2 +从细胞内肌浆网Ca2 +存储中释放

The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

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