A probiotic strain of Escherichia coli Nissle 1917 given orally exerts local and systemic anti-inflammatory effects in lipopolysaccharide-induced sepsis in mice

摘要

Background and purpose:Escherichia coli Nissle 1917 is a probiotic strain used in the treatment of intestinal immune diseases, including ulcerative colitis. The aim of the present study was to test if this probiotic bacterium can also show systemic immunomodulatory properties after oral administration.