Combined pharmacological block of IKr and IKs increases short-term QT interval variability and provokes torsades de pointes

摘要

Background and purpose:Assessing the proarrhythmic potential of compounds during drug development is essential. However, reliable prediction of drug-induced torsades de pointes arrhythmia (TdP) remains elusive. Along with QT interval prolongation, assessment of the short-term variability of the QT interval (STV(QT)) may be a good predictor of TdP. We investigated the relative importance of IKs and IKr block in development of TdP together with correlations between QTc interval, QT interval variability and incidence of TdP.