Neuroprotective and anticonvulsant effects of EGIS-8332 a non-competitive AMPA receptor antagonist in a range of animal models

摘要

Background and purpose:Blockade of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors is a good treatment option for a variety of central nervous system disorders. The present study evaluated the neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, as a potential drug candidate.