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The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

机译：新型内源性大麻素受体GPR55被非典型大麻素激活但不介导其血管舒张作用

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摘要

Background and purpose:Atypical cannabinoids are thought to cause vasodilatation through an as-yet unidentified ‘CBx' receptor. Recent reports suggest GPR55 is an atypical cannabinoid receptor, making it a candidate for the vasodilator ‘CBx' receptor. The purpose of the present study was to test the hypothesis that human recombinant GPR55 is activated by atypical cannabinoids and mediates vasodilator responses to these agents.

机译：背景和目的：非典型大麻素被认为通过尚未鉴定的“ CBx”受体引起血管舒张。最近的报道表明，GPR55是一种非典型的大麻素受体，使其成为血管扩张剂“ CBx”受体的候选者。本研究的目的是检验非典型大麻素激活人重组GPR55并介导对这些药物的血管舒张反应的假设。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
D G Johns; D J Behm; D J Walker; Z Ao; E M Shapland; D A Daniels; M Riddick; S Dowell; P C Staton; P Green; U Shabon; W Bao; N Aiyar; T-L Yue; A J Brown; A D Morrison; S A Douglas;
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作者单位

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年(卷),期 2007(152),5
年度 2007
页码 825–831
总页数 7
原文格式 PDF
正文语种
中图分类药学 ;
关键词
GPR55 cannabinoid receptors abnormal cannabidiol CBx receptor;

机译：GPR55;大麻素受体;异常大麻素;CBx受体;

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1. The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55 [J] . Haleli Sharir, Linda Console-Bram, Christina Mundy, Journal of Neuroimmune Pharmacology . 2012 ,第4期

机译：内源性大麻素Anandamide和Virodhamine调节候选大麻素受体GPR55的活性
2. O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment [J] . Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Frontiers in Neuropharmacology . 2020 ,第a期

机译：O-1602，非典型大麻素受体GPR55的激动剂，逆转了对皮质酮治疗的大鼠抑郁症和抑制剂过度症的症状
3. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress [J] . Qi-xin Shi, Liu-kun Yang, Wen-long Shi, Molecular brain . 2017 ,第1期

机译：新型大麻素受体GPR55介导急性应激小鼠的眶内侧皮质抗焦虑作用
4. Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes [C] . Jürgen Kraus International Society for Neuroimmunomodulation . 2012

机译：μ-ApiOID受体和大麻素受体1型在T淋巴细胞中的表达和功能
5. The uterotrophic effects of relaxin: Activation of ligand-independent estrogen receptor-mediated transcription. [D] . Pillai, Suresh Biswanath. 2001

机译：松弛素的子宫营养作用：激活不依赖配体的雌激素受体介导的转录。
6. The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55 [O] . Haleli Sharir, Linda Console-Bram, Christina Mundy, -1

机译：内源性大麻素花生四烯酸乙醇胺和virodhamine调节候选人的活动大麻素受体GpR55
7. The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects [O] . Johns, D G, Behm, D J, Walker, D J, 2009

机译：新型内源性大麻素受体GPR55被非典型大麻素激活，但不介导其血管舒张作用
8. Anticonvulsant Effects of Dadle are Primarily Mediated by Activation of Opioid Receptors: Interactions between and U Receptor Antagonists [R] . Tortella, F. C., Robles, L., Holaday, J. W. 1985

机译：激活阿片受体主要介导Dadle的抗惊厥作用：U受体拮抗剂之间的相互作用

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

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