A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

机译：兔Langendorff心脏心律失常模型：预测值的扭转型尖峰的临床鉴定的价值。

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摘要

Background and purpose:The rabbit isolated Langendorff heart model (SCREENIT) was used to investigate the proarrhythmic potential of a range of marketed drugs or drugs intended for market. These data were used to validate the SCREENIT model against clinical outcomes.

机译：背景与目的：兔离体朗根多夫心脏模型（SCREENIT）用于研究一系列市售药物或拟上市药物的心律失常潜力。这些数据用于对照临床结果验证SCREENIT模型。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
C L Lawrence; M H Bridgland-Taylor; C E Pollard; T G Hammond; J-P Valentin;
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作者单位

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年(卷),期 2006(149),7
年度 2006
页码 845–860
总页数 16
原文格式 PDF
正文语种
中图分类药学;
关键词
arrhythmia cardiac early after-depolarisations electrophysiology in vitro map monophasic action potential proarrhythmia QT prolongation Torsades de Pointes;

机译：心律失常;心脏;去极化后早期;电生理学;体外;图谱;单相动作电位;心律失常;QT延长;扭转型尖峰;

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专利

1. Editorial to "Disturbances of cardiac wavelength and repolarization precede torsade de pointes and ventricular fibrillation in langendorff perfused rabbit hearts" by Luc Hondeghem It is difficult to make predictions, especially about the future*: Thoughts about forecasting cardiotoxicity of pharmacological interventions [J] . Odening Katja E., Kohl Peter Progress in Biophysics and Molecular Biology: An International Review Journal . 2016,第1期

机译：卢克·洪德格姆（Luc Hondeghem）的社论：“朗格多夫灌流的兔心脏中的心脏波长变化和复极化先于扭转性尖端扭转和心室纤颤发生”很难做出预测，尤其是对未来的预测*：关于预测药物干预措施的心脏毒性的思考
2. Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts [J] . Hondeghem Luc M. Progress in Biophysics and Molecular Biology: An International Review Journal . 2016,第1期

机译：在Langendorff灌注的兔心脏中，在Torsade de Pointes和心室纤颤之前出现了心脏波长和复极的干扰
3. Nonclinical proarrhythmia models: predicting Torsades de Pointes. [J] . Lawrence CL, Pollard CE, Hammond TG, Journal of Pharmacological and Toxicological Methods . 2005,第1期

机译：非临床性心律失常模型：预测Torsades de Pointes。
4. Influence of ischemia on left ventricular depolarization in isolated rabbit hearts perfused according to Langendorff [C] . J. Kolafova, O. Janousek, M. Novakova, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：缺血对根据Langendorff灌注的离体兔心脏左心室去极化的影响
5. Potential mechanisms for drug-induced prolongation of QT interval and genesis of torsades de pointes evaluated in the failing rabbit heart. [D] . Kijtawornrat, Anusak. 2007

机译：在衰竭的心脏中评估了药物引起的QT间隔延长和扭转性扭转的潜在机制。
6. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts [O] . A Sugiyama 2008

机译：灵敏可靠的心律失常的体内动物模型用于预测心脏重构患者的药物诱发的尖端扭转型室速
7. A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes [O] . Lawrence, C L, Bridgland-Taylor, M H, Pollard, C E, 2006

机译：兔Langendorff心脏心律失常模型：预测值的扭转型尖峰的临床鉴定的价值。

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

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