A Comparative Study of the Liver Damage and Worm Burden in Mice Following Infection with Schistosoma mansoni from Northern and Southern Sudan

摘要

Host-parasite relationship and liver damage were studied in experimental schistosomiasis in albino mice utilizing Schistosoma mansoni of Northern and Southern Sudan. Mice were infected with single doses of 180 cercariae of either S. mansoni “North” or S. mansoni “South”. There was some evidence of both early prepatency and liver damage, a high percentage of both cercarial penetration and worm recovery in mice infected with S. mansoni “South”.A new strain of Biomphalaria sudanica snails were found to be resistant to infection with S. mansoni of both Northern and Southern Sudan. B. pfeifferi snails were susceptible to both S. mansoni “North” and “South”: differences in susceptibility were found to vary with the age of snails, the younger being more susceptible. Infectivity and mortality were higher in case of infection due to S. mansoni “South”.