Complement Fixing Antibody Against Solubilized Placental Microsomal Fraction in Pre-eclampsia Sera

摘要

Placental microsomal fraction was prepared from several term human placentae. A major composite protein (molecular weight 30,000-160,000) was separated by gel filtration of solubilized microsomal fraction. Complement fixing antibody against this protein occurred in 40% of normal pregnancy sera, and in 44·6% of pre-eclampsia sera.