The effect of guanfacine (2 mg once daily) on ambulatory blood pressure was studied with the Remler M 2000 recorder in 16 elderly hypertensive patients during a randomized, double-blind, placebo-controlled, balanced, cross-over study. Guanfacine significantly reduced heart rate and systolic and diastolic ambulatory blood pressure. The antihypertensive effect was maintained over the whole recording period. Systolic and diastolic blood pressure variability was not changed by guanfacine, neither when defined as standard deviation or variation coefficient of the mean, nor when defined as the range between the highest and lowest ambulatory blood pressure, suggesting that blood pressure variability is unrelated to sympathetic nervous system activity.
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机译：在一项随机，双盲，安慰剂对照，平衡，交叉研究中，使用Remler M 2000记录仪研究了胍法辛（每天2 mg一次）对动态血压的影响。胍法辛可显着降低心率以及收缩期和舒张期动态血压。在整个记录期间保持抗高血压作用。胍法辛未改变收缩压和舒张压的变异性，既没有定义为均值的标准差或均值变异系数，也没有定义为最高和最低门诊血压之间的范围，这表明血压变异性与交感神经无关系统活动。
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