Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy

摘要

The study adopted a two-group cross sectional arrangement as shown in this flow chart. Among 53 consecutive patients identified and approached, 50 patients were consented and received wide local excision or mastectomy. After surgery, the freshly excised tumours were scanned on a clinical 3 T MRI scanner to derive lactate concentration within the whole tumour using double quantum filtered (DQF) magnetic resonance spectroscopy (MRS). Subsequently, histopathological analysis provided tumour grade, size, histological type, lactate dehydrogenase A and B (LDH-A and LDH-B), Ki-67 expression and Nottingham Prognostic Index (NPI). Thirty patients with invasive ductal carcinoma (IDC) (15 grade II and 15 grade III) were eventually entered into the study and used for all statistical analysis.