Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma

摘要

CHOEP treatment induces cell cycle perturbations and cell death in preclinical models of T-cell lymphoma. , Cell lines were exposed to IC CHOEP for 24 h and 48 h. Cell cycle distribution ( ) and FITC–Annexin V/PI staining ( ) were evaluated by flow cytometry. In panel , early apoptotic cells are Annexin V positive/PI negative, late apoptoticecrotic cells are Annexin V positive/PI positive. The data are the mean ± SD of three independent experiments. Asterisks indicate statistically significant differences (*  p p a, differences are referred to the untreated sample. In panel , statistics was calculated on the total number of dead cells