A key genomic subtype associated with lymphovascular invasion in invasive breast cancer

摘要

Cumulative survival of BC patients stratified by LVI status. Ten-year overall survival in the METABRIC cases was significantly worse in the LVI-positive group than in the LVI-negative group. In TCGA cases, significant differences were noted in patient overall survival in the LVI-positive and LVI-negative groups. Cumulative survival of breast cancer patients stratified by LVI-related genomic subtypes. Ten-year overall survival in breast cancer patients with LVI-related genomic subtypes. Subtype 2 was significantly worse compared with subtype 1 in the METABRIC cohort. Classification of LVI-related genomic subtype was a significant prognostic factor in the TCGA cohort