Cytokine Adsorption in Cardiac Surgery: where do we stand?

摘要

Cardiopulmonary bypass (CPB) is inexorably linked to varying degrees of inflammatory response activation, mediated by diverse cytokines. A dysregulated cytokine inflammatory response, or a , results in significant systemic hypotension, culminating as multi-organ failure (MOF). Considering the association of the cytokine surge with adverse postoperative outcomes and heightened morbidity and mortality , it has been proposed that the extracorporeal cytokine removal presents the potential of improving the outcomes across heterogeneous clinical scenarios characterized by lethal hyperinflammation.