首页> 美国卫生研究院文献>BMJ Open Access >Original article: Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

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Original article: Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

机译：原始文章：通过基因扩增增加Solute载体家族12成员5的表达有助于肿瘤进展和转移并与大肠癌的不良生存有关

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ObjectiveUsing whole genome sequencing, we identified gene amplification of solute carrier family 12 member 5 (SLC12A5) located at 20q13.12 in colorectal cancer (CRC). We analysed its amplification, overexpression, biological effects and prognostic significance in CRC.

机译：目的通过全基因组测序，我们确定了位于大肠癌（CRC）中位于20q13.12的溶质载体家族12成员5（SLC12A5）的基因扩增。我们分析了其在CRC中的扩增，过表达，生物学效应和预后意义。

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期刊名称 BMJ Open Access
作者
Lixia Xu; Xiaoxing Li; Muyan Cai; Jinna Chen; Xiangchun Li; William K K Wu; Wei Kang; Joanna Tong; Ka-Fai To; Xin-Yuan Guan; Joseph J Y Sung; Francis K L Chan; Jun Yu;
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年(卷),期 -1(65),4
年度 -1
页码 635–646
总页数 12
原文格式 PDF
正文语种
中图分类
关键词
COLORECTAL CANCER GENE EXPRESSION MOLECULAR ONCOLOGY TUMOUR MARKERS;

机译：大肠癌;基因表达;分子肿瘤;肿瘤标志物;

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专利

1. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer [J] . Xu Lixia, Li Xiaoxing, Cai Muyan, Gut: Journal of the British Society of Gastroenterology . 2016,第4期

机译：通过基因扩增增加Solute载体家族12成员5的表达有助于肿瘤进展和转移，并与大肠癌的不良生存相关
2. Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer [J] . Jing Shi, Yiping Qu, Xinru Li, Cell death & disease. . 2016,第10期

机译：通过基因扩增增加 EHF 的表达有助于激活HER家族信号传导，并与胃癌的不良存活率相关
3. Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer [J] . Liu Liguo, Yang Yi, Zhou Xueming, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：溶质载体家族34成员2次过度表达有助于肿瘤生长和结直肠癌的患者存活差
4. Integrating Protein Family Sequence Similarities with Gene Expression to Find Signature Gene Networks in Breast Cancer Metastasis [C] . Sepideh Babaei, Erik van den Akker, Jeroen de Ridder, Pattern recognition in bioinformatics . 2011

机译：整合蛋白质家族序列相似性与基因表达以寻找乳腺癌转移中的签名基因网络
5. H3K18 and H4K12 acetylation and the expression of HDAC2 and the progression of colorectal cancer. [D] . Belgrave, Kevin O'neal. 2008

机译：H3K18和H4K12的乙酰化以及HDAC2的表达和结直肠癌的进展。
6. Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer [O] . Jing Shi, Yiping Qu, Xinru Li, 2016

机译：通过基因扩增增加EHF的表达有助于HER家族信号的激活并与胃癌的不良生存相关
7. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer [O] . Wu WK, Yu J, Chan FK, 2016

机译：通过基因扩增增加溶质载体家族12成员5的表达有助于肿瘤进展和转移并且与结肠直肠癌的不良存活相关联

Original article: Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

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