Neuroprotective effect of Demethoxycurcumin a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells

机译：姜黄素的天然衍生物去甲氧基姜黄素对鱼藤酮诱导的SH-SY 5Y神经母细胞瘤细胞神经毒性的保护作用

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BackgroundMitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson’s disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity.

机译：背景线粒体功能障碍和氧化应激是导致帕金森氏病（PD）多巴胺能神经元死亡的主要毒性事件，被确定为治疗代祷的重要目标。这项研究调查了去甲氧基姜黄素（DMC）的神经保护作用，姜黄素的衍生物对鱼藤酮诱导的神经毒性。

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期刊名称 BMC Complementary and Alternative Medicine
作者
Muthu Ramkumar; Srinivasagam Rajasankar; Veerappan Venkatesh Gobi; Chinnasamy Dhanalakshmi; Thamilarasan Manivasagam; Arokiasamy Justin Thenmozhi; Musthafa Mohamed Essa; Ameer Kalandar; Ranganathan Chidambaram;
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年(卷),期 2017(17),-1
年度 2017
页码 217
总页数 11
原文格式 PDF
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中图分类
关键词
Demethoxycurcumin Rotenone Oxidative stress Apoptosis Neurodegenerative diseases;

机译：脱甲氧基姜黄素;鱼藤酮;氧化应激;细胞凋亡;神经退行性疾病;

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1. Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells [J] . Muthu Ramkumar, Srinivasagam Rajasankar, Veerappan Venkatesh Gobi, BMC Complementary and Alternative Medicine . 2017,第1期

机译：姜黄素的天然衍生物去甲氧基姜黄素对鱼藤酮诱导的SH-SY 5Y神经母细胞瘤细胞神经毒性的保护作用
2. Demethoxycurcumin, a Natural Derivative of Curcumin Abrogates Rotenone-induced Dopamine Depletion and Motor Deficits by Its Antioxidative and Anti-inflammatory Properties in Parkinsonian Rats [J] . Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Pharmacognosy magazine . 2018,第53期

机译：去甲姜黄素，姜黄素的天然衍生物可简化帕金森氏大鼠的抗氧化和抗炎特性，它可替代酮类酮诱导的多巴胺消耗和运动功能障碍。
3. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. [J] . Zhang L, Wu C, Zhao S, International immunopharmacology . 2010,第3期

机译：去甲氧基姜黄素，姜黄素的天然衍生物，通过下调脂多糖诱导的N9小胶质细胞内ROS相关的MAPK /NF-κB信号通路，减弱LPS诱导的促炎反应。
4. Neurotoxicity and neuroprotective effect of carbon nanotubes on neuroblastoma cells [C] . Nurulhuda I., Mazatulikhma M. Z., Poh R., 2012 International Conference on Enabling Science and Nanotechnology . 2012

机译：碳纳米管对神经母细胞瘤细胞的神经毒性和神经保护作用
5. Neuroprotective effects of dopamine agonists in terminally differentiated SH-SY5Y neuroblastoma cells. [D] . Presgraves, Steven Preston. 2004

机译：多巴胺激动剂在终末分化的SH-SY5Y神经母细胞瘤细胞中的神经保护作用。
6. Neuroprotective Effects of Proanthocyanidins Natural Flavonoids Derived From Plants on Rotenone-Induced Oxidative Stress and Apoptotic Cell Death in Human Neuroblastoma SH-SY5Y Cells [O] . Jian Ma, Shan-Shan Gao, Hai-Jie Yang, 2018

机译：原花青素植物来源的天然类黄酮对人神经母细胞瘤SH-SY5Y细胞中鱼藤酮诱导的氧化应激和凋亡细胞死亡的神经保护作用。
7. Component of nicotine-induced intracellular calcium elevation mediated through α3- and α5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells [O] . Tamayo Takahashi, Takayuki Yoshida, Kana Harada, 2020

机译：尼古丁诱导的细胞内钙升高通过α3和α5烟碱乙酰胆碱受体介导的细胞内钙升高受SH-SY 5Y细胞的循环AMP调节

Neuroprotective effect of Demethoxycurcumin a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells

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