Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines Hyperalgesia and Paw Edema in Adjuvant-Induced Arthritis

摘要

Introduction:Immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. Given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin B1 on the proinflammatory cytokines, edema, and hyperalgesia during the acute and chronic phases of adjuvant-induced arthritis.