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Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

机译：针对性设计的α-2-巨球蛋白（A2M）变异体可减轻前交叉韧带横断所致骨关节炎大鼠模型的软骨变性

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摘要

BackgroundThe study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo.

机译：背景进行这项研究以评估靶向的α-2-巨球蛋白（A2M）变体在野生型（wt）-A2M处是否具有相似或增强的功能以减弱体内软骨变性。

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期刊名称 Arthritis Research
作者
Yang Zhang; Xiaochun Wei; Shawn Browning; Gaetano Scuderi; Lewis S. Hanna; Lei Wei;
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作者单位

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年(卷),期 2017(19),-1
年度 2017
页码 175
总页数 11
原文格式 PDF
正文语种
中图分类外科学;
关键词
Targeted designed variants of A2M PTOA Rat ACLT OA model;

机译：针对性设计的A2M;PTOA;大鼠ACLT OA模型变体;

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专利

1. Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection [J] . Yang Zhang, Xiaochun Wei, Shawn Browning, Arthritis research & therapy. . 2017,第1期

机译：针对性设计的α-2-巨球蛋白（A2M）变异体可减轻前交叉韧带横断所致骨关节炎大鼠模型的软骨变性
2. Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis [J] . Khunakornvichaya Arada, Lekmeechai Sujinna, Phi Phuong Pham, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2016,第5a6期

机译：桑属茎提取物减轻前交叉韧带横断所致大鼠关节炎的疼痛和关节软骨损伤
3. Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis [J] . Khunakornvichaya Arada, Lekmeechai Sujinna, Phi Phuong Pham, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2016,第5a6期

机译：Morus Alba L. Stem提取物衰减疼痛和关节软骨损伤在骨关节炎的骨关节炎大鼠大鼠模型中的疼痛和关节软骨损伤
4. Differential gene expression analysis in a rabbit model of osteoarthritis induced by anterior cruciate ligament (ACL) section [C] . G. Bluteau, J. Gouttenoire, T. Conrozier, Falk Symposium . 2002

机译：前十字韧带（ACL）截面诱导骨关节炎兔模型中的差异基因表达分析
5. The Effect of Low-Magnitude High-Frequency Vibration on Osteoarthritic Cartilage and Subchondral Bone in Anterior Cruciate Ligament Transection-Induced Osteoarthritic Rat Model. [D] . Qin, Jianghui. 2014

机译：低幅高频振动对前交叉韧带横断诱导的骨关节炎大鼠模型的骨关节炎软骨和软骨下骨的影响。
6. Histology Glycosaminoglycan Level and Cartilage Stiffness in Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis with Anterior Cruciate Ligament Transection in Rat Model and Human Osteoarthritis [O] . Sangeetha Vasudevaraj Naveen, Raja Elina Ahmad, Wong Jia Hui, 2014

机译：单碘乙酸盐诱导的骨关节炎的组织学糖胺聚糖水平和软骨刚度：与大鼠模型和人类骨关节炎的前交叉韧带横断比较
7. Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection [O] . Yang Zhang, Xiaochun Wei, Shawn Browning, 2017

机译：靶向设计的α-2-宏观球蛋白（A2M）的设计变体衰减在骨缩韧带横透视诱导的骨关节炎大鼠模型中衰减软骨变性

Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

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