Can metformin stabilize PCSK9 level in stable coronary artery disease patients treated with statins?

机译：二甲双胍能否稳定他汀类药物治疗的稳定冠心病患者的PCSK9水平？

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IntroductionProprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as an important marker of cardiovascular risk and a new target for therapeutic interventions. We aimed to study the influence of metformin on the level of circulating PCSK9 in patients with stable coronary artery disease (SCAD) and type 2 diabetes (T2DM) or metabolic syndrome (MetS), receiving moderate doses of statins used in routine clinical practice.

机译：简介前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）已成为心血管风险的重要标志和治疗干预的新目标。我们旨在研究二甲双胍对稳定冠心病（SCAD）和2型糖尿病（T2DM）或代谢综合征（MetS），接受常规临床实践中使用的他汀类药物的患者循环PCSK9水平的影响。

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期刊名称 Archives of Medical Sciences. Atherosclerotic Diseases
作者
Aleksandr B. Shek; Rano B. Alieva; Ravshanbek D. Kurbanov; Shavkat U. Hoshimov; Ulugbek I. Nizamov; Adolat V. Ziyaeva;
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作者单位

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年(卷),期 2019(4),-1
年度 2019
页码 e144–e150
总页数 7
原文格式 PDF
正文语种
中图分类生理学;
关键词
metformin rosuvastatin proprotein convertase subtilisin/kexin type 9 type 2 diabetes mellitus metabolic syndrome;

机译：二甲双胍;瑞舒伐他汀;前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型;2型糖尿病;代谢综合征;
入库时间 2022-08-17 15:58:11

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1. Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial [J] . Anholm Christian, Kumarathurai Preman, Pedersen Lene Rorholm, Atherosclerosis . 2019,第期

机译：Liraglutide与二甲双胍组合可以改善血液发生脂质曲线和降低血管蛋白治疗患者冠状动脉疾病的肥胖患者的C反应蛋白水平，新诊断的2型糖尿病：随机试验
2. Sonoclot analysis in coronary artery surgery: a comparison between patients with unstable coronary artery disease treated with enoxaparin before surgery and patients with stable coronary artery disease not treated with enoxaparin. [J] . Pleym H, Wahba A, Bjella L, Journal of cardiothoracic and vascular anesthesia . 2008,第5期

机译：冠状动脉手术中的声区分析：术前用依诺肝素治疗的不稳定冠状动脉疾病患者与未用依诺肝素治疗的稳定型冠状动脉疾病患者之间的比较。
3. Does administration of eicosapentaenoic acid increase soluble thrombomodulin level in statin-treated patients with stable coronary artery disease? [J] . Tani Shigemasa, Matsuo Rei, Hirayama Atsushi Heart and vessels: An international journal . 2019,第2期

机译：是否赋予偏辛腺苷酸稳定冠状动脉疾病患者的溶解血栓调节蛋白水平？
4. Selected Markers of Inflammation and Endothelial Dysfunction in Patients with Stable Coronary Artery Disease Treated with PTCA with/without Stent Implantation [C] . W. Kolasinska-Kloch, D. Drobniak-Heldak, M. Kloch, International Congress on Coronary Artery Disease . 2007

机译：用PTCA处理稳定冠状动脉疾病患者的炎症和内皮功能障碍的标记，用/无支架植入
5. A comparison of selected preoperative coronary artery disease risk factors in patients 40 years or younger and patients over 40 years undergoing coronary artery bypass graft surgery. [D] . Frye, Laurie Perry. 2002

机译：比较40岁以下的患者和40岁以上进行冠状动脉搭桥术的患者的术前选择的冠心病危险因素。
6. High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS) [O] . Hiroyuki Daida, Tadateru Takayama, Takafumi Hiro, 2012

机译：高HbA1c水平与稳定型冠状动脉疾病患者在他汀类药物治疗期间斑块退化的减少相关：冠状动脉粥样硬化研究的结果使用血管内超声在日本受试者（COSMOS）中测定了瑞舒伐他汀的作用
7. Can metformin stabilize PCSK9 level in stable coronary artery disease patients treated with statins? [O] . Aleksandr B. Shek, Rano B. Alieva, Ravshanbek D. Kurbanov, 2019

机译：二甲双胍可以在用他汀类药物治疗的稳定冠状动脉疾病患者中稳定PCSK9水平吗？

Can metformin stabilize PCSK9 level in stable coronary artery disease patients treated with statins?

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