Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung Liver and Kidney Tumors: Implications for Cancer Genomics

摘要

Context Targeted needle biopsies are increasingly performed for the genetic characterization of cancer. While the nucleic acid content of core needle biopsies after standard pathology processing (i.e., formalin fixation and paraffin embedding (FFPE)) has been previously reported, little is known about the potential yield for molecular analysis at the time of biopsy sample acquisition.