Gender influences volume regulation via several mechanisms; whether these include microvascular exchange, especially in the heart, is not known. In response to adenosine (Ado), permeability (Ps)to protein of coronary arterioles of female pigs decreases acutely. Whether Ado induces similar Ps changes in arterioles from males or whether equivalent responses occur in coronary venules of either sex has not been determined. Hypotheses that 1) basal Ps properties and 2) Ps responses to vasoactive stimuli are sex independent were evaluated from measures of Ps to two hydrophilic proteins, α-lactalbumin and porcine serum albumin (PSA), in arterioles and venules isolated from hearts of adult male and female pigs. Consistent with hypothesis 1, basal Ps values of both microvessel types were independent of sex. Contrary to hypothesis 2, Ps responses to Ado varied with sex, protein, and vessel type. Confirming earlier studies, Ado induced a ~20% decrease in Ps to both proteins in coronary arterioles from females. In arterioles from males, Ado did not change Ps for α-lactalbumin (, 3 ± 13%) whereas Ps for PSA () decreased by 27 ± 8% (P < 0.005). In venules from females, Ado elevated by 44 ± 20% (P < 0.05), whereas in those from males, Ado reduced by 24 ± 5% (P < 0.05). The variety of outcomes is consistent with transvascular protein and protein-carried solute flux being regulated by multiple sex-dependent mechanisms in the heart and provides evidence of differences in exchange homeostasis of males and females in health and, likely, disease.
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机译:性别通过多种机制影响音量调节。这些是否包括微血管交换,特别是在心脏中,尚不清楚。响应腺苷(Ado),雌猪冠状小动脉蛋白的通透性(Ps)急剧下降。尚未确定Ado是否诱导了男性小动脉中类似的Ps变化,或是否在男女性别的冠状静脉中发生了相同的反应。从成年男性心脏小动脉和小静脉中的Ps对两种亲水蛋白α-乳白蛋白和猪血清白蛋白(PSA)的测量值,评估1)基础Ps特性和2)Ps对血管活性刺激的反应与性别无关的假设。和母猪。与假设1一致,两种微血管的基础Ps值均与性别无关。与假设2相反,Ps对Ado的反应随性别,蛋白质和血管类型的不同而不同。证实了较早的研究,Ado诱导女性冠状小动脉中两种蛋白质的Ps降低了约20%。在雄性小动脉中,Ado不会改变α-乳白蛋白的Ps( P mi> s mi> α mi> -lactalb mtext > mrow> msubsup> mrow> math>,3±13%),而PSA的Ps(展开▼