>Objectives: The number of children who survive cancer is reaching new record levels, thanks to improved management strategies. However, this population is predisposed to chronic health conditions including cardiovascular disease and type 2 diabetes, yet the full scale of these diagnoses in this population is unclear. This protocol describes the conduct of a systematic review to report on the prevalence of diabetes mellitus (DM) subtypes in childhood cancer survivors.>Methods: Searches will be conducted in MEDLINE, Embase, CINAHL, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. We will also search gray literature in Theses A&I, ProQuest Dissertations, and Web of Science as well as clinicaltrials.gov. Screening search results and data abstraction will be done independently by two reviewers. We will conduct a meta-analysis if two studies have similar designs, populations, methods, and outcome measures reported.>Results: The findings of this systematic review will provide insights into the scale of diabetes in childhood cancer survivors to allow the prioritization of subpopulations that need specific interventions to screen, prevent, and treat DM. This will likely lead to improved outcomes in childhood cancer survivors.
展开▼
机译:>目标 strong>:得益于改进的管理策略,幸存下来的儿童人数已达到新的记录水平。然而,该人群易患慢性健康状况,包括心血管疾病和2型糖尿病,但尚不清楚这些人群中这些诊断的全面范围。该协议描述了进行系统综述的过程,以报告儿童癌症幸存者中糖尿病(DM)亚型的患病率。>方法: strong>搜索将在MEDLINE,Embase,CINAHL,Cochrane Systematic数据库中进行评论和Cochrane对照试验中央注册簿。我们还将在论文A&I,ProQuest Dissertations,Web of Science和Clinicaltrials.gov中搜索灰色文献。筛选搜索结果和数据抽象将由两名审阅者独立完成。如果两项研究报告了相似的设计,人群,方法和结果指标,我们将进行荟萃分析。>结果 strong>:本系统综述的结果将为儿童癌症幸存者中糖尿病的规模提供见解以便对需要特定干预措施以筛查,预防和治疗DM的亚人群进行优先排序。这可能会改善儿童癌症幸存者的预后。
展开▼