Copper-Catalyzed 18FFluorination of (Mesityl)(aryl)iodoniumSalts

摘要

A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [¹⁸F]KF to access ¹⁸F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[¹⁸F]fluorophenylalanine and 6-[¹⁸F]fluoroDOPA.