循环内皮祖细胞数量与抑郁症的关系研究

摘要

Objective To investigate circulating endothelial progenitor cells(EPCs) counts in patients with depression,and explore the relationship between endothelial dysfunctions and depression status.Methods Peripheral blood samples were collected from patients with depression (n=30) and matched healthy subjects (n=30).EPCs were labeled with CD34,CD133 and vascular endothelial growth factor receptor- 2 (VEGFR2) antibodies and counted by flow cytometry.Results CD34+, CD34+/KDR+, CD133+/KDR+ and CD34+/CD133+/KDR+ EPC counts were decreased in patients with depression compared to controls (P＜ 0.05); and the CD34+, CD34+/CD133+/KDR+EPC levels were negatively correlated with HAMD scores of patients.Conclusion The circulating EPCs counts in patients with depression decrease and negatively correlated with the severity of depression.%目的 抑郁症患者外周血中循环内皮祖细胞(EPCs)数量的变化,探讨抑郁症患者血管内皮功能的改变及其与抑郁状态的关系.方法 选择抑郁症患者30例为病例组,正常健康成人30例为对照组,以CD34、CD133/AC133、VEGFR2/KDR荧光抗体标记EPCs,采用流式细胞仪检测两组循环EPCs的CD34+、CD34+/KDR+、CD133+/KDR+、CD34+/CD133+/KDR+表达情况.结果 抑郁症组的CD34+、CD34+/KDR+、CD133+/KDR+、CD34+/CD133+/KDR+细胞数均明显低于对照组,差异均有统计学意义(均P＜0.05).Pearson相关分析显示汉密尔顿抑郁量表总分与循环EPCs CD34+、CD34+/CD133+/KDR+细胞数呈负相关(P＜0.05),与CD34+/KDR+、CD133+/KDR+细胞数无相关关系(P ＞0.05).结论抑郁症患者的循环EPCs数量减少,且EPCs水平与抑郁症状的严重程度存在负相关.