Objective To compare the effect on neurological recovery and activities of daily living (ADL) between aspirin or clopidogrel in patients with acute cerebral infarction. Methods Eighty nine patients with acute cerebral infarction admitted from January 2010 to June 2011 were randomly assigned into two groups:patients in aspirin group received 200mg/d aspirin for 2 weeks and patients in clopidogrel group received 75mg/d clopidogrel for 2 weeks. The neural function deficit and ADL of patients were assessed with Stroke Patients Clinical Neural Function Defect Score Standards (1995) and Barthel Index Score of ADL re-spectively before and 14, 90 days after treatment. Results There were no significant differences in neural function and ADL at d14 after treatment between two groups (P>0.05);however, at d90 after treatment the indexes of clopidogrel group were better than those of aspirin groups (P<0.05). Conclusion Clopidogrel is more effective than aspirin for neurological recovery in patient with acute cerebral infarction.% 目的探讨阿司匹林与氯吡格雷对急性脑梗死患者神经功能恢复及日常生活能力(ADL)的影响.方法选择神经内科住院治疗的急性脑梗死患者89例，通过抛硬币法随机分为阿司匹林组和氯吡格雷组，分别给予阿司匹林和氯吡格雷口服治疗，并于入院时、治疗第14天和第90天进行神经功能缺损程度和ADL的评分.结果两组患者治疗第14天神经功能及ADL均有恢复，但两组的差异无统计学意义(P>0.05)；治疗第90天神经功能及ADL恢复更加明显，且氯吡格雷组均优于阿司匹林组，差异有统计学意义(P<0.05).氯吡格雷组治疗后90d内心脑血管意外事件再发生率少于阿司匹林组，差异有统计学意义(P<0.05).结论氯吡格雷对急性脑梗死患者的神经功能恢复优于阿司匹林.
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